DNA repair-deficiency disorder

11 oxo zsírvesztés

Tartalom

    Hereditary nonpolyposis colorectal cancer HNPCC is very often caused by a defective MSH2 gene leading to defective mismatch repairbut displays no symptoms of "accelerated aging".

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    Debate concerning "accelerated aging"[ edit ] Some biogerontologists question that such a thing as "accelerated aging" actually exists, at least partly on the grounds that all of the so-called accelerated aging diseases are segmental progerias. Many disease conditions such as diabeteshigh blood pressureetc. Without reliable biomarkers of aging it is hard to support the claim that a disease condition represents more than accelerated mortality.

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    It is further argued that segmental aging phenotype is a natural part of aging insofar as genetic variation leads to some people being more disposed than others to aging-associated diseases such as cancer and Alzheimer's disease. Then the repair function will likely be deficient, and, as a consequence, damages 11 oxo zsírvesztés tend to accumulate. Germ-line DNA repair mutations that increase the risk of cancer are listed in the Table.

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